翻訳と辞書 Words near each other ・ Heat Radio ・ Heat rate ・ Heat rate (efficiency) ・ Heat recovery steam generator ・ Heat recovery ventilation ・ HEAT repeat domain ・ Heat rock ・ Heat rub ・ Heat Rush ・ Heat sealer ・ Heat Seekers ・ Heat shield ・ Heat Shield Rock ・ Heat shock ・ Heat shock factor ・ Heat shock protein ・ Heat shock protein 47 ・ Heat shock protein 70 (Hsp70) internal ribosome entry site (IRES) ・ Heat shock protein 90kDa alpha (cytosolic), member A1 ・ Heat sink ・ Heat sink (disambiguation) ・ Heat spreader ・ Heat stabilization ・ Heat storage ・ Heat stroke ・ Heat syncope ・ Heat Team ・ Heat therapy ・ Heat torch ・ Heat transfer Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Heat shock protein ： ウィキペディア英語版 Heat shock protein Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock, but are now known to also be expressed during other stresses including exposure to cold, UV light, and during wound healing or tissue remodeling.〔.〕 Many members of this group perform chaperone function by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress. This increase in expression is transcriptionally regulated. The dramatic upregulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat shock factor (HSF). HSPs are found in virtually all living organisms, from bacteria to humans. Heat-shock proteins are named according to their molecular weight. For example, Hsp60, Hsp70 and Hsp90 (the most widely-studied HSPs) refer to families of heat shock proteins on the order of 60, 70, and 90 kilodaltons in size, respectively. The small 8-kilodalton protein ubiquitin, which marks proteins for degradation, also has features of a heat shock protein. ==Discovery== It is known that rapid heat hardening can be elicited by a brief exposure of cells to sub-lethal high temperature, which in turn provides protection from subsequent and more severe temperature. In 1962, Italian geneticist Ferruccio Ritossa reported that heat and the metabolic uncoupler 2,4-dinitrophenol induced a characteristic pattern of puffing in the chromosomes of Drosophila. This discovery eventually led to the identification of the heat-shock proteins (HSP) or stress proteins whose expression these puffs represented. Increased synthesis of selected proteins in Drosophila cells following stresses such as heat shock was first reported in 1974. Beginning in the mid-1960s, investigators recognized that many HSPs function as molecular chaperones and thus play a critical role in protein folding, intracellular trafficking of proteins, and coping with proteins denatured by heat and other stresses. Therefore, the study of stress proteins has undergone explosive growth. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Heat shock protein」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.